Product classification
HS code for Methadone: 2922.39
Amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function, salts thereof, excluding amfepramone (INN), methadone (INN), and normethadone (INN) and salts thereof.
Classification of methadone under HS 2922.39
Methadone is classified under HS code 2922.39. This classification is part of the group for oxygen-function amino-compounds, specifically amino-aldehydes, amino-ketones, and amino-quinones. Methadone is a synthetic opioid that contains both an amine group and a ketone group within its molecular structure. Under the Harmonized System, Chapter 29 covers organic chemicals, and Heading 2922 is dedicated to amino-compounds with oxygen functions. While the specific subheading 2922.31 is often designated for certain INN substances like Amfepramone and Methadone in many versions of the tariff, the "Other" category 2922.39 is used for related salts, derivatives, or specific chemical variations not explicitly named in the preceding subheadings. The classification depends on the chemical identity as an amino-ketone that does not contain more than one kind of oxygen function (i.e., it contains only the amine and the ketone/aldehyde/quinone function).
- Covers
- Methadone (INN)
- Methadone hydrochloride
- Salts of methadone
- Methadone intermediates (specific amino-ketone forms)
- Isomethadone
- Also under 2922.39
- Alfa Aesar 4-Aminobenzophenone
- Acros Organics 2-Aminoacetophenone
- Santa Cruz Biotechnology 3-Aminopropiophenone
- Fisher Scientific 4-Amino-2-methylbenzaldehyde
Codes often confused with 2922.39
Common mistake. Methadone is often misclassified under HS code 2933, which covers heterocyclic compounds with nitrogen hetero-atom(s) only. However, because methadone's nitrogen is part of an open chain (acyclic) rather than a ring, it belongs in 2922. It is also frequently confused with HS code 3004 if it is prepared as a finished pharmaceutical (e.g., oral solution or tablets). If the product is the bulk active pharmaceutical ingredient (API), it must be classified in Chapter 29, not Chapter 30.
Top exporters and importers of HS 292239 (the code used for methadone), 2025
In 2025, the largest exporter of HS 292239 (the code used for methadone) in UN Comtrade data was India, with 30% of world exports; the largest importer in UN Comtrade data was Germany, with 21% of world imports. Countries that did not report 2025 data are estimated from partner records, which can understate them.
Figures cover everything classified under HS 292239, not only methadone.
Top exporters 2025 · share of world exports
- 1 India $49M 30% of world exports
- 2 China $44M 27% of world exports
- 3 United States $22M 13% of world exports
World total: $164M Reported figures on UN Comtrade ↗
Top importers 2025 · share of world imports
- 1 Germany $32M 21% of world imports
- 2 United States $16M 11% of world imports
- 3 Canada $14M 9.4% of world imports
World total: $150M Reported figures on UN Comtrade ↗
How these figures are built
109 countries reported 2025 trade to UN Comtrade in HS 2022, and their own totals are used. Countries that did not report are estimated from what other countries recorded trading with them. Those estimates miss trade with other non-reporting countries, so they can be low, and a non-reporting country can rank higher than shown or be missing from the list. World totals add both and leave out trade between two non-reporting countries. Figures are in current US dollars; reported imports are mostly valued CIF and exports FOB, and exports include re-exports. The UN Comtrade links show the underlying records; they can also list a few reporters left out here (regional groups and older HS editions).
Source: UN Comtrade (United Nations Statistics Division), 2025 annual data.
Brazil NCM codes for methadone
Brazil splits HS 2922.39 into 4 NCM codes. Pick the one that matches your product:
- 2922.39.10Aminoanthraquinones and their salts
- 2922.39.21Ketamine hydrochloride
- 2922.39.29Ketamine and salts other than hydrochloride
- 2922.39.90Other amino-aldehydes, -ketones, -quinones; salts
Source: Siscomex NCM table, updated Oct 2026. The Portuguese text on each NCM page is the official one.
Questions about methadone
What is the HS code for Methadone?
The HS code for Methadone is 292239 (Amino-aldehydes, amino-ketones and amino-quinones; other than those containing more than one kind of oxygen function; salts thereof, excluding amfepramone (INN), methadone (INN), and normethadone (INN) and salts thereof). Methadone and its salts are generally classified under 2922.31 or 2922.39, depending on the specific national tariff schedule and the purity of the compound.
How do I classify Methadone for customs?
Methadone is classified under HS code 292239 — Amino-aldehydes, amino-ketones and amino-quinones; other than those containing more than one kind of oxygen function; salts thereof, excluding amfepramone (INN), methadone (INN), and normethadone (INN) and salts thereof. This is a 6-digit subheading level code.
Why is Methadone in Chapter 29 and not Chapter 30?
Chapter 29 is for separate chemically defined compounds (bulk chemicals). Chapter 30 is for medicaments that have been mixed or put up in dosage forms for therapeutic use.
Which countries are the top exporters of methadone (HS 292239)?
In 2025, the top exporters of HS 292239 (the code used for methadone) in UN Comtrade data were India ($49M, 30% of world exports), China ($44M) and the United States ($22M). World exports came to about $164M, adding countries' reported figures and partner-based estimates for those that did not report (UN Comtrade data). Countries that did not report 2025 data are estimated from partner records, which can understate them.
Which countries are the top importers of methadone (HS 292239)?
In 2025, the top importers of HS 292239 (the code used for methadone) in UN Comtrade data were Germany ($32M, 21% of world imports), the United States ($16M) and Canada ($14M). World imports came to about $150M, adding countries' reported figures and partner-based estimates for those that did not report (UN Comtrade data). Countries that did not report 2025 data are estimated from partner records, which can understate them.
Is the HS code for Methadone the same in all countries?
The base HS code 292239 for Methadone is internationally standardized for the first 6 digits across 200+ countries. Individual countries may add additional digits for national tariff lines and specific classifications.
What is the NCM code for methadone in Brazil?
Brazil splits HS 292239 into 4 NCM codes, so the right one for methadone depends on the product's details: 2922.39.10 (Aminoanthraquinones and their salts), 2922.39.21 (Ketamine hydrochloride), 2922.39.29 (Ketamine and salts other than hydrochloride), 2922.39.90 (Other amino-aldehydes, -ketones, -quinones; salts).