HS code · 6-digit subheading

HS Code 2933.59 – Heterocyclic compounds; containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure, (other than malonylurea and its derivatives, loprazolam, mecloqualone, methaqualone, zipeprol, and salts thereof) n.e.c. in 2933.5

HS code 2933.59 is the 6-digit subheading for heterocyclic compounds, containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure, (other than malonylurea and its derivatives, loprazolam, mecloqualone, methaqualone, zipeprol, and salts thereof) n.e.c. in 2933.5. It is used for piperazine, pyrimidine, buspirone, sildenafil citrate and ciprofloxacin.

What HS 2933.59 covers

This HS code encompasses a broad range of heterocyclic compounds characterized by the presence of a pyrimidine or piperazine ring in their molecular structure, excluding specific controlled substances and malonylurea derivatives. These compounds are vital intermediates and active pharmaceutical ingredients (APIs) in the chemical and pharmaceutical industries. They serve as building blocks for synthesizing a vast array of drugs, agrochemicals, and specialty chemicals. Major importers and exporters include pharmaceutical giants, fine chemical manufacturers, and research institutions globally. Countries with strong chemical industries, such as Germany, Switzerland, China, India, and the United States, are key players in both production and trade. The trade involves both bulk quantities for industrial synthesis and smaller, high-purity batches for research and development. Understanding the specific chemical properties and intended end-use is crucial for proper classification and compliance, as many of these compounds, while not controlled themselves, can be precursors to regulated substances or have specific handling requirements. The market is driven by innovation in drug discovery and the demand for new materials in various industrial applications.

Covers
  • Piperazine
  • Pyrimidine
  • Buspirone
  • Sildenafil citrate
  • Ciprofloxacin
  • Ropinirole
  • Olanzapine
  • Quetiapine
Examples
  • Viagra (Sildenafil)
  • Cipro (Ciprofloxacin)
  • Zyprexa (Olanzapine)
  • Seroquel (Quetiapine)

Codes often confused with 2933.59

Common mistake. This code is a "basket" category for pyrimidine/piperazine compounds not elsewhere specified. It's often confused with 293355 (specific controlled substances) or other specific pharmaceutical API codes if the compound has a more precise classification elsewhere.

2933.55Heterocyclic compounds; containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure; loprazolam (INN), mecloqualone (INN), methaqualone (INN), and zipeprol (INN); salts thereof

Top exporters and importers of HS code 293359, 2025

In 2025, the largest exporter of HS code 293359 in UN Comtrade data was Switzerland, with 42% of world exports; the largest importer in UN Comtrade data was Slovenia, with 32% of world imports. Countries that did not report 2025 data are estimated from partner records, which can understate them.

Top exporters 2025 · share of world exports

  1. 1 Switzerland $11.0B
  2. 2 Ireland $5.5B
  3. 3 Slovenia $3.8B

World total: $26.2B Reported figures on UN Comtrade ↗

Top importers 2025 · share of world imports

  1. 1 Slovenia $8.4B
  2. 2 United States $4.0B
  3. 3 Germany $3.6B

World total: $26.4B Reported figures on UN Comtrade ↗

How these figures are built

109 countries reported 2025 trade to UN Comtrade in HS 2022, and their own totals are used. Countries that did not report are estimated from what other countries recorded trading with them. Those estimates miss trade with other non-reporting countries, so they can be low, and a non-reporting country can rank higher than shown or be missing from the list. World totals add both and leave out trade between two non-reporting countries. Figures are in current US dollars; reported imports are mostly valued CIF and exports FOB, and exports include re-exports. The UN Comtrade links show the underlying records; they can also list a few reporters left out here (regional groups and older HS editions).

Source: UN Comtrade (United Nations Statistics Division), 2025 annual data.

Brazil NCM codes for 2933.59 26

Brazil splits HS 2933.59 into 26 NCM codes, Mercosur's 8-digit tariff lines.

  1. 2933.59.1 Containing a piperazine ring in the structureCuja estrutura contém um ciclo piperazina Group
  2. 2933.59.11 OxatomideOxatomida
  3. 2933.59.12 PraziquantelPraziquantel
  4. 2933.59.13 Norfloxacin and its nicotinateNorfloxacina e seu nicotinato
  5. 2933.59.14 Flunarizine and its dihydrochlorideFlunarizina e seu dicloridrato
  6. 2933.59.15 Enrofloxacin; piperazine saltsEnrofloxacina; sais de piperazina
  7. 2933.59.16 Buspirone hydrochlorideCloridrato de buspirona
  8. 2933.59.19 Other piperazine ring compoundsOutros
  9. 2933.59.2 Containing a pyrimidine ring (whether or not hydrogenated) and covalently bonded halogens in the structureCuja estrutura contém um ciclo pirimidina (hidrogenado ou não) e halogênios em ligação covalente Group
  10. 2933.59.21 BromacilBromacil
  11. 2933.59.22 TerbacilTerbacil
  12. 2933.59.23 FluorouracilFluorouracil
  13. 2933.59.29 Other halogenated pyrimidine compoundsOutros
  14. 2933.59.3 Containing a pyrimidine ring (whether or not hydrogenated) and sulphur, but not covalently bonded halogens, in the structureCuja estrutura contém um ciclo pirimidina (hidrogenado ou não) e enxofre, mas não contém halogênios em ligação covalente Group
  15. 2933.59.31 PropylthiouracilPropiltiouracil
  16. 2933.59.32 DiazinonDiazinon
  17. 2933.59.33 PyrazophosPirazofós
  18. 2933.59.34 AzathioprineAzatioprina
  19. 2933.59.35 6-Mercaptopurine6-Mercaptopurina
  20. 2933.59.39 Other halogen-free sulphur-containing pyrimidinesOutros
  21. 2933.59.4 Containing a pyrimidine ring (whether or not hydrogenated) and alcohol or ether functions, or both, but not covalently bonded halogens or sulphur, in the structureCuja estrutura contém um ciclo pirimidina (hidrogenado ou não) e funções álcool, éter ou ambas, mas não contém halogênios em ligação covalente nem enxofre Group
  22. 2933.59.41 TrimethoprimTrimetoprima
  23. 2933.59.42 AciclovirAciclovir
  24. 2933.59.43 Dipyridamole tosilatesTosilatos de dipiridamol
  25. 2933.59.44 NicarbazinNicarbazina
  26. 2933.59.45 Menadione dimethylpyrimidinol bisulphiteBissulfito de menadiona dimetilpirimidinol
  27. 2933.59.49 Other pyrimidine alcohols/ethers, no S or halogensOutros
  28. 2933.59.9 OtherOutros Group
  29. 2933.59.91 MinoxidilMinoxidil
  30. 2933.59.92 2-Aminopyrimidine2-Aminopirimidina
  31. 2933.59.99 Other pyrimidine or piperazine ring compoundsOutros

All Brazil NCM codes in heading 29.33 →

Source: Siscomex NCM table, updated Oct 2026. The Portuguese text is official; the English is our translation.

Questions about HS 2933.59

What is HS code 293359?

HS code 293359 is a 6-digit subheading in the Harmonized System that covers: Heterocyclic compounds; containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure, (other than malonylurea and its derivatives, loprazolam, mecloqualone, methaqualone, zipeprol, and salts thereof) n.e.c. in 2933.5. This HS code encompasses a broad range of heterocyclic compounds characterized by the presence of a pyrimidine or piperazine ring in their molecular structure, excluding specific controlled substances and malonylurea derivatives. These compounds are vital intermediates and active pharmaceutical ingredients (APIs) in the chemical and pharmaceutical industries. They serve as building blocks for synthesizing a vast array of drugs, agrochemicals, and specialty chemicals. Major importers and exporters include pharmaceutical giants, fine chemical manufacturers, and research institutions globally. Countries with strong chemical industries, such as Germany, Switzerland, China, India, and the United States, are key players in both production and trade. The trade involves both bulk quantities for industrial synthesis and smaller, high-purity batches for research and development. Understanding the specific chemical properties and intended end-use is crucial for proper classification and compliance, as many of these compounds, while not controlled themselves, can be precursors to regulated substances or have specific handling requirements. The market is driven by innovation in drug discovery and the demand for new materials in various industrial applications.

What products fall under HS code 293359?

Piperazine, Pyrimidine, Buspirone, Sildenafil citrate, Ciprofloxacin, Ropinirole, Olanzapine, Quetiapine

What are common misclassifications for HS code 293359?

This code is a "basket" category for pyrimidine/piperazine compounds not elsewhere specified. It's often confused with 293355 (specific controlled substances) or other specific pharmaceutical API codes if the compound has a more precise classification elsewhere.

Which countries are the top exporters of goods under HS code 293359?

In 2025, the top exporters of HS code 293359 in UN Comtrade data were Switzerland ($11.0B, 42% of world exports), Ireland ($5.5B) and Slovenia ($3.8B). World exports came to about $26.2B, adding countries' reported figures and partner-based estimates for those that did not report (UN Comtrade data). Countries that did not report 2025 data are estimated from partner records, which can understate them.

Which countries are the top importers of goods under HS code 293359?

In 2025, the top importers of HS code 293359 in UN Comtrade data were Slovenia ($8.4B, 32% of world imports), the United States ($4.0B) and Germany ($3.6B). World imports came to about $26.4B, adding countries' reported figures and partner-based estimates for those that did not report (UN Comtrade data). Countries that did not report 2025 data are estimated from partner records, which can understate them.

How is HS code 293359 structured?

HS code 293359 is a 6-digit subheading under the Harmonized System. The first 2 digits (29) identify the chapter, digits 3-4 (33) identify the heading, and digits 5-6 (59) specify the subheading. This code is standardized globally by the World Customs Organization.

What is the Brazil NCM code for HS code 293359?

Brazil splits HS code 293359 into 26 NCM codes: 2933.59.11 (Oxatomide), 2933.59.12 (Praziquantel), 2933.59.13 (Norfloxacin and its nicotinate), 2933.59.14 (Flunarizine and its dihydrochloride), 2933.59.15 (Enrofloxacin; piperazine salts), 2933.59.16 (Buspirone hydrochloride), 2933.59.19 (Other piperazine ring compounds), 2933.59.21 (Bromacil), and more listed on this page. The first 6 digits of each match the HS code.